Publications

Harry L Hébert, Abirami Veluchamy, Georgios Baskozos, Francesca Fardo, Dimitri M L Van Ryckeghem, Mathilde M V Pascal, Claire Jones, Keith Milburn, Ewan R Pearson, Geert Crombez, David L H Bennett, Weihua Meng, Colin N A Palmer, Blair H Smith. Cohort Profile: DOLORisk Dundee – A longitudinal study of chronic neuropathic pain. BMJOpen. 2021 [accepted for publication].

Troels S Jensen, Pall Karlsson, Sandra S Gylfadottir, Signe T Andersen, David L Bennett, Hatice Tankisi, Nanna B Finnerup, Astrid J Terkelsen, Karolina Khan, Andreas C Themistocleous, Alexander G Kristensen, Mustapha Itani, Søren H Sindrup, Henning Andersen, Morten Charles, Eva L Feldman, Brian C Callaghan. Painful and non-painful diabetic neuropathy, diagnostic challenges and implications for future management. Brain [published online 12 March 2021]. doi: 10.1093/brain/awab079

Pall Karlsson, Sandra S. Gylfadottir, Alexander G. Kristensen, Juan D. Ramirez, Pedro Cruz, Nhu Le, Pallai R. Shillo, Solomon Tesfaye, Andrew S. C. Rice, Hatice Tankisi, Nanna B. Finnerup, Jens R. Nyengaard, Troels S. Jensen, David L. H. Bennett, Andreas C. Themistocleous. Axonal swellings are related to type 2 diabetes, but not to distal diabetic sensorimotor polyneuropathy. Diabetologia. 2021; 64(4): 923–931. doi: 10.1007/s00125-020-05352-9 [PubMed] [Open Access on PMC]

Julia Forstenpointner, Ruth Ruscheweyh, Nadine Attal, Ralf Baron, Didier Bouhassira, Elena K. Enax-Krumova, Nanna B. Finnerup, Rainer Freynhagen, Janne Gierthmühlen, Per Hansson, Troels S. Jensen, Christoph Maier, Andrew S.C. Rice, Märta Segerdahl, Thomas Tölle, Rolf-Detlef Treede, Jan Vollert. No pain, still gain (of function): the relation between sensory profiles and the presence or absence of self-reported pain in a large multicenter cohort of patients with neuropathy. Pain. 2021 Mar 1;162(3):718-727. doi: 10.1097/j.pain.0000000000002058 [PubMed]

Kristine Bennedsgaard, Lise Ventzel, Niels T. Andersen, Andreas C. Themistocleous, David L. Bennett, Troels S. Jensen, Hatice Tankisi, Nanna B. Finnerup. Oxaliplatin‐ and docetaxel‐induced polyneuropathy: clinical and neurophysiological characteristics. J Peripher Nerv Syst. 2020 Dec; 25(4): 377–387. doi: 10.1111/jns.12413 [PubMed] [Open Access on PMC]

Signe Vogel, Sandra Sif Gylfadottir, Nanna Brix Finnerup, Troels Staehelin Jensen. Diabetic polyneuropathy and neuropathic pain: findings from a qualitative study. Pract Diab. 2020 Nov 37: 211-215. doi: 10.1002/pdi.2307 [Open Access on PMC]

Blair H. Smith, Harry L. Hébert, Abirami Veluchamy. Neuropathic pain in the community: prevalence, impact, and risk factors. Pain. 2020 Sep;161 Suppl 1:S127-S137. doi: 10.1097/j.pain.0000000000001824 [PubMed] [Open Access]

Ernest Turro, William J. Astle, Karyn Megy, Stefan Gräf, Daniel Greene, Olga Shamardina, Hana Lango Allen, Alba Sanchis-Juan, Mattia Frontini, Chantal Thys, Jonathan Stephens, Rutendo Mapeta, Oliver S. Burren, Kate Downes, Matthias Haimel, Salih Tuna, Sri V. V. Deevi, Timothy J. Aitman, David L. Bennett, Paul Calleja, Keren Carss, Mark J. Caulfield, Patrick F. Chinnery, Peter H. Dixon, Daniel P. Gale, Roger James, Ania Koziell, Michael A. Laffan, Adam P. Levine, Eamonn R. Maher, Hugh S. Markus, Joannella Morales, Nicholas W. Morrell, Andrew D. Mumford, Elizabeth Ormondroyd, Stuart Rankin, Augusto Rendon, Sylvia Richardson, Irene Roberts, Noemi B. A. Roy, Moin A. Saleem, Kenneth G. C. Smith, Hannah Stark, Rhea Y. Y. Tan, Andreas C. Themistocleous, Adrian J. Thrasher, Hugh Watkins, Andrew R. Webster, Martin R. Wilkins, Catherine Williamson, James Whitworth, Sean Humphray, David R. Bentley, Nathalie Kingston, Neil Walker, John R. Bradley, Sofie Ashford, Christopher J. Penkett, Kathleen Freson, Kathleen E. Stirrups, F. Lucy Raymond, Willem H. Ouwehand Whole-genome sequencing of patients with rare diseases in a national health system. Nature. 2020 Jul 1; 583(7814): 96–102. doi: 10.1038/s41586-020-2434-2 [PubMed] [doi: 10.1002/cam4.3129 [PubMed] [Open Access on PMC]

Kristine Bennedsgaard, Lise Ventzel, Peter Grafe, Jenny Tigerholm, Andreas C. Themistocleous, David L. Bennett, Hatice Tankisi, Nanna B. Finnerup. Cold aggravates abnormal excitability of motor axons in oxaliplatin‐treated patients. Muscle Nerve. 2020 Jun; 61(6): 796–800. doi: 10.1002/mus.26852 [PubMed] [Open Access on PMC]

Geert Crombez, Annick L. De Paepe, Elke Veirman, Christopher Eccleston, Gregory Verleysen, Dimitri M.L. Van Ryckeghem. Let’s talk about pain catastrophizing measures: an item content analysis. PeerJ. 2020; 8: e8643. doi: 10.7717/peerj.8643 [PubMed] [Open Access]

Margarita Calvo, Alexander J. Davies, Harry L. Hébert, Greg A. Weir, Elissa J. Chesler, Nanna B. Finnerup, Roy C. Levitt, Blair H. Smith, G. Gregory Neely, Michael Costigan, David L. Bennett. The Genetics of Neuropathic Pain from Model Organisms to Clinical Application. Neuron. 2019 Nov 20; 104(4): 637–653. doi: 10.1016/j.neuron.2019.09.018 [PubMed] [Open Access on PMC]

Pascal MMV, Themistocleous AC, Baron R, Binder A, Bouhassira D, Crombez G, Finnerup NB, Gierthmühlen J, Granovsky Y, Groop L, Hebert HL, Jensen TS, Johnsen K, McCarthy MI, Meng W, Palner CNA, Rice ASC, Serra J, Solà R, Yarnitsky D, Smith BH, Attal N, Bennett DLH. DOLORisk: study protocol for a multi-centre observational study to understand the risk factors and determinants of neuropathic pain [version 2; peer review: 2 approved]. Wellcome Open Res 2019, 3:63. doi: 10.12688/wellcomeopenres.14576.2 [PubMed] [Open Access on PMC]

Veirman E, Van Ryckeghem D, De Paepe A, Kirtley O, Crombez G. Multidimensional screening for predicting pain problems in adults: a systematic review of screening tools and validation studies. Pain Rep. 2019 Sep 11;4(2019):e775. doi: 10.1097/PR9.0000000000000775 [Open Access]

Meng W, Adams MJ, Palmer CAN, 23andMe Research Team, Shi J, Auton A, Ryan KA, Jordan JM, Mitchell BD, Jackson RD, Yau MS, McIntosh AM, Smith BH. Genome-wide association study of knee pain identifies associations with GDF5 and COL27A1 in UK Biobank. Commun Biol. 2019 Aug 28;2:321. doi: 10.1038/s42003-019-0568-2 [PubMed] [Open Access on PMC]

Wei W, Tuna S, Keogh MJ, Smith KR, Aitman TJ, Beales PL, Bennett DL, Gale DP, Bitner-Glindzicz MAK, Black GC, Brennan P, Elliott P, Flinter FA, Floto RA, Houlden H, Irving M, Koziell A, Maher ER, Markus HS, Morrell NW, Newman WG, Roberts I, Sayer JA, Smith KGC, Taylor JC, Watkins H, Webster AR, Wilkie AOM, Williamson C; NIHR BioResource–Rare Diseases; 100,000 Genomes Project–Rare Diseases Pilot, Ashford S, Penkett CJ, Stirrups KE, Rendon A, Ouwehand WH, Bradley JR, Raymond FL, Caulfield M, Turro E, Chinnery PF. Germline selection shapes human mitochondrial DNA diversity. Science. 2019 May 24;364(6442). pii: eaau6520. doi: 10.1126/science.aau6520 [PubMed] [Open Access]
McDermott LA, Weir GA, Themistocleous AC, Segerdahl AR, Blesneac I, Baskozos G, Clark AJ, Millar V, Peck LJ, Ebner D, Tracey I, Serra J, Bennett DL. Defining the Functional Role of NaV1.7 in Human Nociception. Neuron. 2019 Mar 6;101(5):905-919.e8. doi: 10.1016/j.neuron.2019.01.047 [PubMed] [Open Access on PMC]
Baskozos G, Dawes JM, Austin JS, Antunes-Martins A, McDermott L, Clark AJ, Trendafilova T, Lees JG, McMahon SB, Mogil JS, Orengo C, Bennett DL. Comprehensive analysis of long noncoding RNA expression in dorsal root ganglion reveals cell-type specificity and dysregulation after nerve injury. Pain. 2019 Feb;160(2):463-485. doi: 10.1097/j.pain.0000000000001416 [PubMed] [Open Access on PMC]
Han C, Themistocleous AC, Estacion M, Dib-Hajj FB, Blesneac I, Macala L, Fratter C, Bennett DL, Waxman SG, Dib-Hajj SD. The Novel Activity of Carbamazepine as an Activation Modulator Extends from NaV1.7 Mutations to the NaV1.8-S242T Mutant Channel from a Patient with Painful Diabetic Neuropathy. Mol Pharmacol. 2018 Nov;94(5):1256-1269. doi: 10.1124/mol.118.113076 [PubMed] [Open Access]
Themistocleous AC, Crombez G, Baskozos G, Bennett DL. Using stratified medicine to understand, diagnose, and treat neuropathic pain. Pain. 2018 Sep;159 Suppl 1:S31-S42. doi: 10.1097/j.pain.0000000000001301 [PubMed] [Open Access on PMC]

van Zuydam NR, Ahlqvist E, Sandholm N, et al. A Genome-Wide Association Study of Diabetic Kidney Disease in Subjects With Type 2 Diabetes. Diabetes. 2018 Jul;67(7):1414-1427. doi: 10.2337/db17-0914 [PubMed] [Open Access]

Sieberg CB, Taras C, Gomaa A, Nickerson C, Wong C, Ward C, Baskozos G, Bennett DLH, Ramirez JD, Themistocleous AC, Rice ASC, Shillo PR, Tesfaye S, Edwards RR, Andrews NA, Berde C, Costigan M. Neuropathic pain drives anxiety behavior in mice, results consistent with anxiety levels in diabetic neuropathy patients. Pain Rep. 2018 May 24;3(3):e651. doi: 10.1097/PR9.0000000000000651 [PubMed] [Open Access on PMC]

Veluchamy A, Hébert HL, Meng W, Palmer CNA, Smith BH. Systematic review and meta-analysis of genetic risk factors for neuropathic pain. Pain 2018 May;159(5):825-848. doi: 10.1097/j.pain.0000000000001164 [PubMed] [Open Access]

Blesneac I, Themistocleous AC, Fratter C, Conrad LJ, Ramirez JD, Cox JJ, Tesfaye S, Shillo PR, Rice ASC, Tucker SJ, Bennett DLH. Rare Nav1.7 variants associated with painful diabetic peripheral neuropathy. Pain 2018 Mar;159(3):469-480. doi: 10.1097/j.pain.0000000000001116 [PubMed] [Open Access on PMC]

Hébert HL, Shepherd B, Milburn K, Veluchamy A, Meng W, Carr F, Donnelly LA, Tavendale R, Leese G, Colhoun HM, Dow E, Morris AD, Doney AS, Lang CC, Pearson ER, Smith BH, Palmer CNA. Cohort Profile: Genetics of Diabetes Audit and Research in Tayside Scotland (GoDARTS). International Journal of Epidemiology 2018 Apr; 47(2): 380–381j. doi: 10.1093/ije/dyx140 [PubMed] [Open Access on PMC]

Forstenpointner J, Otto J, Baron R. Individualized neuropathic pain therapy based on phenotyping: are we there yet? Pain. 2018 Mar;159(3):569-575. doi: 10.1097/j.pain.0000000000001088 [PubMed]

Heide R, Bostock H, Ventzel L, Grafe P, Bergmans J, Fuglsang-Frederiksen A, Finnerup NB, Tankisi H. Axonal excitability changes and acute symptoms of oxaliplatin treatment: In vivo evidence for slowed sodium channel inactivation. Clin Neurophysiol. 2018 Mar;129(3):694-706. doi: 10.1016/j.clinph.2017.11.015 [PubMed] [Open Access]

Segerdahl AR, Themistocleous AC, Fido D, Bennett DL, Tracey I. A brain-based pain facilitation mechanism contributes to painful diabetic polyneuropathy. Brain. 2018 Feb 1;141(2):357-364. doi: 10.1093/brain/awx337 [PubMed] [Open Access on PMC]

Meng W, Adams MJ, Hebert HL, Deary IJ, McIntosh AM, Smith BH. A Genome-Wide Association Study Finds Genetic Associations with Broadly-Defined Headache in UK Biobank (N=223,773). EBioMedicine. 2018 Feb;28:180-186. doi: 10.1016/j.ebiom.2018.01.023 [PubMed] [Open Access on PMC]

Terkelsen AJ, Karlsson P, Lauria G, Freeman R, Finnerup NB, Jensen TS. The diagnostic challenge of small fibre neuropathy: clinical presentations, evaluations, and causes. Lancet Neurol. 2017 Nov;16(11):934-944. doi: 10.1016/S1474-4422(17)30329-0 [PubMed] [Open Access]
Weir GA, Middleton SJ, Clark AJ, Daniel T, Khovanov N, McMahon SB, Bennett DL. Using an engineered glutamate-gated chloride channel to silence sensory neurons and treat neuropathic pain at the source. Brain. 2017 Oct 1;140(10):2570-2585. doi: 10.1093/brain/awx201 [PubMed] [Open Access on PMC]

Vollert J, Maier C, Attal N, Bennett DL, Bouhassira D, Enax-Krumova EK, Finnerup NB, Freynhagen R, Gierthmühlen J, Haanpää M, Hansson P, Hüllemann P, Jensen TS, Magerl W, Ramirez JD, Rice AS, Schuh-Hofer S, Segerdahl M, Serra J, Shillo PR, Sindrup S, Tesfaye S, Themistocleous AC, Tölle TR, Treede RD, Baron R. Stratifying patients with peripheral neuropathic pain based on sensory profiles: algorithm and sample size recommendations. Pain 2017 Aug;158(8):1446-1455. doi: 10.1097/j.pain.0000000000000935 [PubMed] [Open Access on PMC]

Hébert HL, Veluchamy A, Torrance N, Smith BH. Risk factors for neuropathic pain in diabetes mellitus. Pain 2017 Apr;158(4):560-568. doi: 10.1097/j.pain.0000000000000785 [PubMed] [Open Access on PMC]

Feldman EL, Nave KA, Jensen TS, Bennett DLH. New Horizons in Diabetic Neuropathy: Mechanisms, Bioenergetics, and Pain. Neuron. 2017 Mar 22;93(6):1296-1313. doi: 10.1016/j.neuron.2017.02.005 [PubMed] [Open Access on PMC]

Colloca L, Ludman T, Bouhassira D, Baron R, Dickenson AH, Yarnitsky D, Freeman R, Truini A, Attal N, Finnerup NB, Eccleston C, Kalso E, Bennett DL, Dworkin RH, Raja SN. Neuropathic pain. Nature Reviews Disease Primers 2017 Feb;3:17002. doi: 10.1038/nrdp.2017.2 [PubMed] [Open Access on PMC]

Baron R, Maier C, Attal N, Binder A, Bouhassira D, Cruccu G, Finnerup NB, Haanpää M, Hansson P, Hüllemann P, Jensen TS, Freynhagen R, Kennedy JD, Magerl W, Mainka T, Reimer M, Rice AS, Segerdahl M, Serra J, Sindrup S, Sommer C, Tölle T, Vollert J, Treede RD. Peripheral neuropathic pain: a mechanism-related organizing principle based on sensory profiles. Pain 2017 Feb;158(2):261-272. doi: 10.1097/j.pain.0000000000000753 [PubMed] [Open Access on PMC]

Cruccu G, Finnerup NB, Jensen TS, Scholz J, Sindou M, Svensson P, Treede RD, Zakrzewska JM, Nurmikko T. Trigeminal neuralgia: New classification and diagnostic grading for practice and research. Neurology 2016 Jul;87(2):220-8. doi: 10.1212/WNL.0000000000002840 [PubMed] [Open Access on PMC]

Kennedy DL, Kemp HI, Ridout D, Yarnitsky D, Rice AS. Reliability of Conditioned Pain Modulation: a Systematic Review. Pain 2016 Nov;157(11):2410–2419. doi: 10.1097/j.pain.0000000000000689 [PubMed] [Open Access on PMC]

Finnerup NB, Haroutounian S, Kamerman P, Baron R, Bennett DL, Bouhassira D, Cruccu G, Freeman R, Hansson P, Nurmikko T, Raja SN, Rice AS, Serra J, Smith BH, Treede RD, Jensen TS. Neuropathic pain: An updated grading system for research and clinical practice. Pain 2016 Aug;157(8):1599–1606. doi: 10.1097/j.pain.0000000000000492 [PubMed] [Open Access on PMC]

Themistocleous AC, Ramirez JD, Shillo PR, Lees JG, Selvarajah D, Orengo C, Tesfaye S, Rice AS, Bennett DL. The Pain in Neuropathy Study (PiNS): a cross-sectional observational study determining the somatosensory phenotype of painful and painless diabetic neuropathy. Pain 2016 May;157(5):1132-45. doi: 10.1097/j.pain.0000000000000491 [PubMed] [Open Access on PMC]

van Hecke O, Kamerman PR, Attal N, Baron R, Bjornsdottir G, Bennett DL, Bennett MI, Bouhassira D, Diatchenko L, Freeman R, Freynhagen R, Haanpää M, Jensen TS, Raja SN, Rice AS, Seltzer Zʼev, Thorgeirsson TE, Yarnitsky D, Smith BH. Neuropathic pain phenotyping by international consensus (NeuroPPIC) for genetic studies: a NeuPSIG systematic review, Delphi survey, and expert panel recommendations. Pain 2015 Nov;156(11):2337-53. doi: 10.1097/j.pain.0000000000000335 [PubMed] [Open Access on PMC]