Work Package 4:

The influence of sensory phenotype on the risk of developing neuropathic pain


Objectives

1) To evaluate sensory phenotypes of neuropathic pain as risk factors for chronicity

2) To establish novel sensory profiling tools for predicting chronic neuropathic pain

3) To correlate predictive sensory phenotypes with genetic and electrophysiological analyses

Description of work

In this work package led by Nanna Finnerup (Aarhus) we will determine whether certain patterns of sensory perceptions are predictive of chronicity of neuropathic pain. Patients with neuropathic pain form different individual patterns or mosaics of sensory symptoms, the sensory profile. The mechanism-based classification scheme states that distinct mechanisms of pain generation produce specific sensory abnormalities. Suggesting that distinct underlying mechanisms are likely associated with risk of chronicity. There are no definite biomarkers with which to ascertain individual pain mechanism and risk factors. Thus, one has to rely on surrogate markers that are likely to be associated with mechanisms and risk. One promising approach is to assess the individual profile of pain-related sensory abnormalities and the sensory perception induced by external stimuli (sensory profiling) as an indirect clinical assessment tool to achieve this aim.

WP leader: Aarhus Universitet