Specific objectives are to:
- Identify the influence of demographic factors, environmental/societal and clinical factors on the risk of developing and maintenance of neuropathic pain;
- Apply modern genomics to validate (using a targeted approach) and find novel (using genome wide association) genetic risk factors for neuropathic pain;
- Use tissue samples and patient derived cells from Biobanks to validate of molecular pathways contributing to chronic pain in patients;
- Determine if patient stratification using physiological (sensory profile, endogenous analgesic mechanisms and nerve excitability) and psychological factors can predict neuropathic pain risk and progression;
- Develop a risk model/algorithm for (severe) neuropathic pain, combining measurable genetic and environmental factors.
Our aim is to understand pain pathophysiology in terms of risk factors and protective mechanisms ranging from molecular pathways to societal impacts. The desired impact is to provide a firm platform to improve diagnosis and stratify patients according to risk profile, employ preventive strategies and ultimately develop novel therapeutics.